The Bubonic Plauge (The Black Death)
Symptoms of the Plague are: Enlarged or painful lymph nodes, chills, headache, fever, and weakness, black boils that emit puss and blood. The black boils were a staple of the black death.
This defined Europe for about a century. The plague ruined Europe. Over 20 million people died in this horrible plague and many people didn't want to come there.