February 1, 1902 – May 22, 1967
Both of Hughes' paternal great-grandmothers were African-American and both of his paternal great-grandfathers were white slave owners of Kentucky. According to Hughes, one of these men was Sam Clay, a Scottish-American whiskey distiller of Henry County and supposedly a relative of Henry Clay, and the other was Silas Cushenberry a Jewish-American slave trader of Clark County. Hughes's maternal grandmother Mary Patterson was of African-American, French, English and Native American descent. One of the first women to attend Oberlin College, she first married Lewis Sheridan Leary, also of mixed race. Lewis Sheridan Leary subsequently joined John Brown's Raid on Harper's Ferry in 1859 and died from his wounds.
In 1869 the widow Mary Patterson Leary married again, into the elite, politically active Langston family. Her second husband was Charles Henry Langston, of African-American, Native American, and Euro-American ancestry. He and his younger brother John Mercer Langston worked for the abolitionist cause and helped lead the Ohio Anti-Slavery Society  in 1858. Charles Langston later moved to Kansas, where he was active as an educator and activist for voting and rights for African Americans. Charles and Mary's daughter Caroline was the mother of Langston Hughes.
Hughes in 1902
Langston Hughes was born in Joplin, Missouri, the second child of school teacher Carrie (Caroline) Mercer Langston and James Nathaniel Hughes (1871–1934). Langston Hughes grew up in a series of Midwestern small towns. Hughes's father left his family and later divorced Carrie, going to Cuba, and then Mexico, seeking to escape the enduring racism in the United States.
After the separation of his parents, while his mother traveled seeking employment, young Langston Hughes was raised mainly by his maternal grandmother, Mary Patterson Langston, in Lawrence, Kansas. Through the black American oral tradition and drawing from the activist experiences of her generation, Mary Langston instilled in her grandson a lasting sense of racial pride. He spent most of his childhood in Lawrence, Kansas. After the death of his grandmother, he went to live with family friends, James and Mary Reed, for two years. In Big Sea he wrote, "I was unhappy for a long time, and very lonesome, living with my grandmother. Then it was that books began to happen to me, and I began to believe in nothing but books and the wonderful world in books — where if people suffered, they suffered in beautiful language, not in monosyllables, as we did in Kansas".
"I was a victim of a stereotype. There were only two of us Negro kids in the whole class and our English teacher was always stressing the importance of rhythm in poetry. Well, everyone knows, except us, that all Negroes have rhythm, so they elected me as class poet."
During high school in Cleveland, he wrote for the school newspaper, edited the yearbook, and began to write his first short stories, poetry, and dramatic plays. His first piece of jazz poetry, "When Sue Wears Red", was written while he was in high school.