Fragile X Syndrome


  • Fragile X Syndrome as known as (FXS)
  • FXS is a genetic disorder.  A gene disorder means that there are changes to a person genes. FXS is caused by changes in the fragile x mental retardation 1(FMR1) gene.
  • People who have FXS do not make this protein.
  • There is no cure to FXS. There are treatment services that help learn important skills.

Definition coming from Center of Diseases control and prevention.


  • Fragile X syndrome is the most common inherited form of mental retardation.(Intellectual Disease)
  • Fragile X is a change in a single gene, the Fragile X Mental Retardation 1 (FMR1)gene.

Symptoms/ Behaviors


  • Symptoms occur because the mutated gene cannot produce enough protein.


  • Development delays such as not sitting, walking or talking at the same time as other children the same age.
  • 5 main signs :
  • Intelligence and learning: Children withFXS have impaired intellectual fuction which affect their ability to think, reason and learn. Researchers measure the fuctions with an IQ test.
  • Physical: Children with FXS have broad foreheads and larger heads
  • Social and emotional : Males: extreme anxiety with aggression  Females: mild anxiety with no aggression
  • Speech and language:  Males: stutter or leave out sounds Females: normal speech patterns
  • Sensory: Children with FXS are sensitive to sensation

Teaching Strategies

Here are a few links to help further understand Fragile X or get support if you or family member are dealing with Fragile X.

  • Avoid direct eye contact
  • Provide visual aids
  • Plan for transitions throughout the day
  • Give personal space
  • Allow children freedom to move around
  • Be aware of behavior triggers

National Fragile X Foundation 1-800-688-8767;

NICHD p.o box 3006Rockville, MD 20847;1-800-370-2943;

The ARC of the United States-1010 Wayne Avenue, Suite 650, Silver Spring, MD 20910; 301-565-3842; fax 301-565-3843;

New Statistics

Males are usually diagnosed with FXS between 35 to 37 months and females by 42 months.

About 47% of families reported FXS caused them financial burden.

62% changed work hours or because a stay at home parent because they have a child with FXS.

44% of females with FXS become independent in their adult years opposed to 9% of males.

Resources Links

32Education. (2012, January 2). Retrieved April 13, 2015, from


Facts about Fragile X Syndrome. (2015, March 9). Retrieved April 13, 2015, from

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