Smith-Magenis Syndrome

Cassandra Brown

Is a developmental disorder that affects many parts of the body.

The major feature of this condition include mild to moderate intellectual disability, distinctive facial features, sleep disturbances and behavioral problems.

Affects 1 out of 25,000 , it is also believed that SMS is under-diagnosed.


SMS is typically not inherited. This condition usually results from a genetic change that occurs during the formation of reproductive cells or the early fetal development.

Most often people with SMS have no history of the conditiopn in their family.


SMS is usually conformed by blood test called chromosome analysis

Children with SMS  are often given psychiatric diagnosis such as autism, attention deficit/hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), attention dificit disorder (ADD) and/or mood disorders


Treatment for SMS relies on managing its symptoms.

Melatonin supplements and trazodone are commonly used to regulate their sleep distrubances


Short stature, abnormal curvature of spine and redused sensitivity to pain and temperature.

They include frequent temper tantrums and outburst, aggression, anxiety, inpulsiveness and difficulty paying attention.

Self-injury including bitting, hitting, head banging and skin picking.

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