von Willebrand Disease

Maddie Darnold

What is it?

Deficiency or impairment of a protein called von Willebrand factor, an important component in the blood clotting process


Inherited defect in the gene that control on Willebrand factor

When von Willebrand factor is scare, the platelets cannot stick together properly, causing excessive bleeding.


  • Recurrent and prolonged nosebleeds
  • Bleeding from the gums
  • Increased menstrual flow
  • Excessive bleeding from a cut or following a tooth extraction or other dental procedure
  • Blood in the stool or urine
  • Bleeding from shaving with a razor or other similarly minor injury
  • Easy bruising
  • Bruises with lumps that form underneath the skin

Diagnostic Tests

  • von Willebrand Factor Antigen blood test
  • Ristocetin cofactor activity
  • Platelet function test

How many people have this disease?

1 in 100


no prevention

Risk factors

A family history of von Willebrand disease is the leading risk factor. A parent can pass the abnormal gene for the disease to their child

The disease is most often "autosomal dominant inherited" which means you only need an abnormal gene from one parent to contract the disease. If you have the gene for von Willebrand disease, you have a 50 percent chance of passing the disease on to your children


Swelling and pain

Death from over bleeding


Desmopressin, a medication administered in a vein or via a nasal spray

Replacement therapies that help to produce clotting factors in your blood

Clot stabalizing medications

Fibrin sealants placed on a wound to clot the blood and seal the wound

Works cited

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