Tay-Sachs Disease and
What is incomplete dominance?
incomplete dominance: a heterozygous condition in which both alleles at a gene locus are partially expressed and which often produces an intermediate phenotype.
does not follow the simple dominant/recessive rules that Mendel applied to genetics
One allele is not completely dominant over the other.
The heterozygous phenotype is a blending of the two homozygous phenotypes.
Results in a third phenotype: combination of the two parent phenotypes.
Tay-Sachs disease is a type of incomplete dominance.
What is Tay-Sachs disease?
Tay-Sachs disease is a rare, inherited disorder that destroys nerve cells in the brain and spinal cord over time.
Tay-Sachs and genetics: gene that makes antibodies only makes half the necessary antibodies.
Mutations in the HEXA gene cause Tay-Sachs.
Inherited in an autosomal recessive pattern- this means that both copies of the gene in each cell have mutations.