Tay-Sachs Disease and
Incomplete Dominance

What is incomplete dominance?

incomplete dominance: a heterozygous condition in which both alleles at a gene locus are partially expressed and which often produces an intermediate phenotype.

does not follow the simple dominant/recessive rules that Mendel applied to genetics

One allele is not completely dominant over the other.

The heterozygous phenotype is a blending of the two homozygous phenotypes.

Results in a third phenotype: combination of the two parent phenotypes.

Tay-Sachs disease is a type of incomplete dominance.

What is Tay-Sachs disease?

Tay-Sachs disease is a rare, inherited disorder that destroys nerve cells in the brain and spinal cord over time.

Tay-Sachs and genetics: gene that makes antibodies  only makes half the necessary antibodies.

Mutations in the HEXA gene cause Tay-Sachs.

Inherited in an autosomal recessive pattern- this means that both copies of the gene in each cell have mutations.

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