Malaria originated in West Africa. It spreads through mosquitoes, which lay their eggs in unsanitary water. These eggs later eat off of blood from other organisms. Which is how humans contract this disease. The country that currently hosts this parasite is West Africa. This means that West Africa holds a large amount of unsanitary water for eggs to hatch.
I do not believe that there will ever be an epidemic because, we have found a cure for this disease. West Africa however; does not have the funds for the cure. An epicdemic of this disease could cause Civil Wars between countries fighting for low remedies. The economy would be spent out on finding more remedies and more ingredients for the cure.